NATIONAL UNIVERSITY OF SINGAPORE Hiring! Full Time Research Fellow (Physics) in West Region (Singapore), Earn up to SGD 5,750 - Ricebowl

Interested applicants are invited to apply directly at the NUS Career Portal. Please note your application will only be processed if you apply via NUS Career Portal.

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We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof Yan Jie on designing and validating AI-generated binders  under a project on Advancing AI Models for Protein–Protein Interaction and Binder Design with Applications to Force-Bearing Cytoskeletal Proteins.

The main responsibilities of the position include:

1. Developing and applying AI-based methods to design or predict binders targeting key domains of mechanosensing proteins.
2. Performing single-molecule manipulation experiments to characterize how these binders modulate the mechanical properties of mechanosensing proteins.
3. Investigating the effects of the designed binders on cellular mechanosensing functions.

Qualifications

• Qualifications / Discipline:
1. Ph.D. in single-molecule biophysics or a closely related field.
2. Strong understanding of protein structure and the mechanical properties of proteins.
3. Prior experience in single-molecule force spectroscopy, protein engineering, or mechanobiology is preferred.

• Skills:
1. Hands-on experience with magnetic tweezers or related single-molecule force spectroscopy techniques.
2. Experience with molecular dynamics simulations for studying protein structure, dynamics, and mechanical properties.
3. Ability to integrate single-molecule experimental data with computational modelling to understand protein mechanosensing mechanisms.

• Experience:  
Demonstrated experience in using magnetic tweezers to perform single-molecule manipulation studies of protein domains, including the characterization of force-dependent conformational changes and mechanical stability.