Job Description

The National University of Singapore invites applications for Research Assistant/ Research Associate (QC Analytical Chemist) in the Department of Clinical Imaging Research Centre (CIRC) Yong Loo Lin School of Medicine. CIRC is a dedicated molecular imaging research centre. It is equipped with on-site capability for the preparation of PET radiopharmaceuticals in a state-of-the-art GMP-certified facility. CIRC is positioned to support both academic and commercially led clinical research programs, with dedicated clinical imaging facilities area advanced modalities of PET-CT and PET-MRI. For more details on what we do, do visit ************* Appointments will be made on a two-years contract basis with the possibility of extension.

Purpose of the post

The QC Analytical Chemist will be responsible to, and work closely with Head of QC, to ensure the successful and safe release of radiopharmaceuticals manufactured at CIRC. The QC Analytical Chemist’s principal role will be to perform all quality control tests required by pharmacopeia. Alongside with maintaining the inventory of raw materials, maintenance of equipment and all the necessary documentation required for the QC laboratory in compliance to PIC/S GMP.

Main Duties and Responsibilities

The QC Analytical Chemist will be responsible for:

• Performing routine QC release testing (HPLC, GC, radioTLC etc) on radiopharmaceutical to ensure quality and safe for clinical use in compliance with PIC/S GMP requirements.
• Support routine QC operations such as daily equipment checks, monthly standard calibration, documentation activities.
• Conducting routine microbial testing activities such as microbial plate incubation, sterility testing, bioburden testing, etc and liaising with third party contractors if required.
• Managing raw materials, including inventory control, purchasing, receipt and status tracking of raw materials.
• Developing and validating QC test methods for the radiopharmaceutical QC release testing.
• Assisting in preparation and maintenance of Standard Operating Procedures (SOPs), Work Instructions (WIN), Recordsheets (REC), etc and fill in Batch Manufacturing Records (BMR).
• Supporting in the managing of equipment in the QC and Metabolite laboratories, including qualification, operation, maintenance, cleaning, calibration and re-qualification activities.
• Supporting Production in Research & Development activities when required.
• Maintaining cleanliness and housekeeping within QC laboratories, raw material storage areas, and the cyclotron facility.
• Handling chemical and biohazard waste disposal activities for QC department in accordance with safety and regulatory requirements.
• Adhering to the university’s safety and health policies and guidelines.
• Performing environmental monitoring activities in cleanroom facilities, including environmental and airborne particle sampling, when required
• Undergoing cross-training to support routine radiopharmaceutical manufacturing activities in Production, where necessary.
• Any adhoc duties assigned in support of departmental and operational needs

Physical Demands and Work Environment

Personnel should be comfortable with:

• exposure to radiation when handling radioactive samples.
• handling of chemicals for QC testing (flammables, acids, and bases).
• Handling chemical and biohazard waste
• Occasion lifting heavy objects such as lead shield containment (lead pots)
• Comfortable with routine and repetitive work
• Standard working hours with occasional overtime

Qualifications

The applicant should:

(a) Have a minimum of BSc degree in Chemistry, Biochemistry, pharmacy or a related field;

(b) Good knowledge and experience on GMP (Good Manufacturing Practice) or GLP (Good Laboratory Practice);

(c) Preferably hands-on experience with operating and maintaining analytical instruments such as HPLC, GC, and also aseptic isolator for sterility testing.

(d) Have good analytical processing skills, as well as,

(e) Have good critical thinking and proactiveness at work

Remuneration will be commensurate with the candidate’s qualifications and experience.

Formal application: Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of three (3) referees to this job portal.

We regret that only shortlisted candidates will be notified.

More Information

Location: Kent Ridge Campus

Organization: Yong Loo Lin School of Medicine

Department : Dean-Med-Clinical Imaging Research Centre

Employee Referral Eligible: No

Job requisition ID : 28267