全职 Pharmacology Scientist 工作, 薪水, Sci.bio Recruiting 公司招聘中 - Ricebowl

We’re looking for a highly execution-focused, hands-on Scientist in Pharmacology to contribute to cardiovascular and metabolic disease programs, particularly in obesity and MASH. This position is well suited for an MS-level scientist with 10+ years of relevant experience who brings strong bench expertise and can independently lead both in vitro, cell-based mechanistic studies and in vivo rodent PK/PD work—delivering complete, high-quality data packages to advance pipeline programs. Experience with RNA or oligonucleotide therapeutics is a plus but not required. What matters most is demonstrated excellence in hands-on pharmacology. If you have a solid track record running metabolic in vitro assays and conducting rigorous in vivo mouse studies, the team can provide training on RNA/oligonucleotide-specific approaches and workflows.

Responsibilities

Study Ownership & Execution

• Design and execute integrated in vitro and in vivo studies aligned with project goals
• Analyze and interpret data to generate clear, decision-ready insights
• Present results and recommendations to project teams
• Manage timelines, identify risks, and troubleshoot effectively

In Vitro Pharmacology (Oligonucleotides)

• Perform ASO/siRNA delivery and transfection
• Conduct dose-response and time-course studies to assess target engagement, potency, and functional outcomes
• Evaluate assay performance, including off-target and cytotoxicity effects

Metabolic Cell Biology & Assays

• Culture and maintain relevant cell models (e.g., hepatocytes, myotubes, adipocytes)
• Run assays related to lipid metabolism, insulin sensitivity, and energy balance
• Perform lipid accumulation, glucose uptake, mitochondrial function, and biomarker assays

Molecular Biology

• Perform qPCR/RT-qPCR, Western blotting, and ELISA/Luminex assays
• Support RNA/protein workflows and data interpretation

In Vivo Pharmacology (Rodent Studies)

• Design and execute mouse studies (lean and DIO models)
• Conduct PK/PD, dose-response, and metabolic assessments (e.g., GTT, ITT, metabolic cages)
• Collect and process blood/tissue samples for downstream analysis
• Ensure compliance with IACUC protocols and animal welfare standards

Data Analysis & Compliance

• Analyze data using standard tools (e.g., Prism, Excel) and apply appropriate statistics
• Maintain accurate documentation and data integrity (ELN)
• Prepare reports and presentations for internal stakeholders
• Ensure compliance with institutional SOPs and regulatory guidelines

Required Skills

• Master’s degree in Life Sciences, Pharmacology, Biomedical Sciences, or a related discipline
• 10+ years of hands-on experience across metabolic in vitro models/assays and rodent in vivo pharmacology, including dosing and tissue collection
• Proven ability to independently design, execute, analyze, and report studies
• Experience authoring and obtaining approval for IACUC protocols (beyond simply following them)
• Strong attention to experimental rigor, including proper controls, thorough documentation, reproducibility, and data integrity
• Effective collaborator with clear communication skills and a strong translational science mindset
• Experience with RNA-based approaches (siRNA/ASO) is a plus, but not required; training can be provided for candidates with solid metabolic and in vivo pharmacology expertise

SGD 58,*************,000